JAK/STAT INHIBITION NORMALIZES LIPID COMPOSITION IN 3D HUMAN EPIDERMAL EQUIVALENTS CHALLENGED WITH TH2 CYTOKINES

JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines

Derangement of the epidermal barrier lipids and dysregulated immune responses Festoon are key pathogenic features of atopic dermatitis (AD).The Th2-type cytokines interleukin IL-4 and IL-13 play a prominent role in AD by activating the Janus Kinase/Signal Transduction and Activator of Transcription (JAK/STAT) intracellular signaling axis.This study

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Predictors of switching from nonsteroidal anti-inflammatory drugs to corticosteroids in patients with acute pericarditis and impact on clinical outcome

Background: Aspirin and nonsteroidal anti-inflammatory drugs (A/NSAIDs) are the mainstay treatments for acute pericarditis.We sought to identify factors predicting failure of A/NSAIDs and switch to corticosteroid treatment (STCT) as well as the impact of STCT on pericarditis recurrence.Methods: We enrolled 148 Seat Adjustment Lever patients with ac

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Intervention Protocol of the Orthopedics and Traumatology Department of a High-Complexity University Hospital to Cope with the COVID-19 Pandemic

Festoon Abstract Objective To describe the protocols implemented to adapt the orthopedic team to the COVID-19 pandemic; a secondary objective is to assess the behavior of hospital and departmental variables when implementing such measures.Methods The present is a retrospective study describing three protocols: 1) reduction in the risk of infection

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Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress

BackgroundThe cell cycle is a critical mechanism Silicone Moulds for proper cellular growth, development and viability.The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g., stress).Accumulating evidence indicates that the prefrontal cortex (PFC) is particularly vulne

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Vertically Aligned NiCo2O4 Nanosheet-Encapsulated Carbon Fibers as a Self-Supported Electrode for Superior Li+ Storage Performance

Binary transition metal oxides (BTMOs) have been explored as promising candidates in rechargeable lithium-ion battery (LIB) anodes due to their high specific capacity and environmental benignity.Herein, 2D ultrathin NiCo2O4 nanosheets vertically grown on a biomass-derived carbon fiber substrate (NCO NSs/BCFs) were obtained by Antenna a facile synth

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